| Match date | Home / Away | Opponent | Competition | Score | PL Points | |
| July 2007 | ||||||
| 07 Sat | Away | Sevenage Borough | Pre-Season friendly | 1-3 | ||
| 12 Thu | Away | St. Patrick's Athletic | Pre-Season friendly | 0-1 | ||
| 21 Sat | Away | Kaizer Chiefs | Vodacom Challenge | Pre-Season friendly | 1-2 | |
| 24 Tue | Away | Orlando Pirates | Vodacom Challenge | Pre-Season friendly | 1-2 | |
| 28 Sat | Away | Orlando Pirates | Vodacom Challenge | Pre-Season friendly | 0-3 | |
| August 2007 | ||||||
| 01 Wed | Away | Leyton Orient | Pre-Season friendly | 2-4 | ||
| 04 Sat | Home | Torino | Pre-Season friendly | 2-0 | ||
| 11 Sat | Away | Sunderland | Barclays Premier League | Matchday 1 | 1-0 | 0 |
| 14 Tue | Home | Everton | Barclays Premier League | Matchday 2 | 1-3 | 0 |
| 18 Sat | Home | Derby County | Barclays Premier League | Matchday 3 | 4-0 | 3 |
| 26 Sun | Away | Manchester United | Barclays Premier League | Matchday 4 | 1-0 | 3 |
| September 2007 | ||||||
| 01 Sat | Away | Fulham | Barclays Premier League | Matchday 5 | 3-3 | 4 |
| 15 Sat | Home | Arsenal | Barclays Premier League | Matchday 6 | 1-3 | 4 |
| 20 Thu | Home | Anorthosis Famagusta | UEFA Cup | Round 1 1st leg | 6-1 | |
| 23 Sun | Away | Bolton Wanderers | Barclays Premier League | Matchday 7 | 1-1 | 5 |
| 26 Wed | Home | Middlesbrough | League cup | Round 3 | 2-0 | |
| October 2007 | ||||||
| 01 Mon | Home | Aston Villa | Barclays Premier League | Matchday 8 | 4-4 | 6 |
| 04 Thu | Away | Anorthosis Famagusta | UEFA Cup | Round 1 2nd leg | 1-1 | |
| 07 Sun | Away | Liverpool | Barclays Premier League | Matchday 9 | 2-2 | 7 |
| 22 Mon | Away | Newcastle United | Barclays Premier League | Matchday 10 | 3-1 | 7 |
| 25 Thu | Home | Getafe | UEFA Cup | Group 1 | 1-2 | |
| 28 Sun | Home | Blackburn Rovers | Barclays Premier League | Matchday 11 | 1-2 | 7 |
| 31 Wed | Home | Blackpool | League cup | Round 4 | 2-0 | |
| November 2007 | ||||||
| 03 Sat | Away | Middlesbrough | Barclays Premier League | Matchday 12 | 1-1 | 8 |
| 08 Thu | Away | Hapoel Tel Aviv | UEFA Cup | Group 2 | 0-2 | |
| 11 Sun | Home | Wigan Athletic | Barclays Premier League | Matchday 13 | 4-0 | 11 |
| 25 Sun | Away | West Ham United | Barclays Premier League | Matchday 14 | 1-1 | 12 |
| 29 Thu | Home | Aalborg | UEFA Cup | Group 3 | 3-2 | |
| December 2007 | ||||||
| 02 Sun | Home | Birmingham City | Barclays Premier League | Matchday 15 | 2-3 | 12 |
| 06 Thu | Away | Anderlecht | UEFA Cup | Group 4 | 1-1 | |
| 09 Sun | Home | Manchester City | Barclays Premier League | Matchday 16 | 2-1 | 15 |
| 15 Sat | Away | Portsmouth | Barclays Premier League | Matchday 17 | 0-1 | 18 |
| 18 Tue | Away | Manchester City | League cup | Round 5 | 0-2 | |
| 22 Sat | Away | Arsenal | Barclays Premier League | Matchday 18 | 2-1 | 18 |
| 26 Wed | Home | Fulham | Barclays Premier League | Matchday 19 | 5-1 | 21 |
| 29 Sat | Home | Reading | Barclays Premier League | Matchday 20 | 6-4 | 24 |
| January 2008 | ||||||
| 01 Tue | Away | Aston Villa | Barclays Premier League | Matchday 21 | 2-1 | 24 |
| 05 Sat | Home | Reading | FA Cup | Round 3 | 2-2 | |
| 09 Wed | Away | Arsenal | League cup | Semi Final 1st leg | 1-1 | |
| 12 Sat | Away | Chelsea | Barclays Premier League | Matchday 22 | 2-0 | 24 |
| 15 Tue | Away | Reading | FA Cup | Replay | 0-1 | |
| 19 Sat | Home | Sunderland | Barclays Premier League | Matchday 23 | 2-0 | 27 |
| 22 Tue | Home | Arsenal | League cup | Semi Final 2nd leg | 5-1 | |
| 27 Sun | Away | Manchester United | FA Cup | Round 4 | 3-1 | |
| 30 Wed | Away | Everton | Barclays Premier League | Matchday 24 | 0-0 | 28 |
| February 2008 | ||||||
| 02 Sat | Home | Manchester United | Barclays Premier League | Matchday 25 | 1-1 | 29 |
| 09 Sat | Away | Derby County | Barclays Premier League | Matchday 26 | 0-3 | 32 |
| 14 Thu | Away | Slavia Prague | UEFA Cup | Round of 32 1st leg | 1-2 | |
| 21 Thu | Home | Slavia Prague | UEFA Cup | Round of 32 2nd leg | 1-1 | |
| 24 Sun | Wembley | Chelsea | League cup | Final | 2-1 | a.e.t. |
| March 2008 | ||||||
| 01 Sat | Away | Birmingham City | Barclays Premier League | Matchday 27 | 4-1 | 32 |
| 06 Thu | Home | PSV Eindhoven | UEFA Cup | Round of 16 1st leg | 0-1 | |
| 09 Sun | Home | West Ham United | Barclays Premier League | Matchday 28 | 4-0 | 35 |
| 12 Wed | Away | PSV Eindhoven | UEFA Cup | Round of 16 2nd leg | 0-1 | |
| 16 Sun | Away | Manchester City | Barclays Premier League | Matchday 29 | 2-1 | 35 |
| 19 Wed | Home | Chelsea | Barclays Premier League | Matchday 30 | 4-4 | 36 |
| 22 Sat | Home | Portsmouth | Barclays Premier League | Matchday 31 | 2-0 | 39 |
| 30 Sun | Home | Newcastle United | Barclays Premier League | Matchday 32 | 1-4 | 39 |
| April 2008 | ||||||
| 05 Sat | Away | Blackburn Rovers | Barclays Premier League | Matchday 33 | 1-1 | 40 |
| 12 Sat | Home | Middlesbrough | Barclays Premier League | Matchday 34 | 1-1 | 41 |
| 19 Sat | Away | Wigan Athletic | Barclays Premier League | Matchday 35 | 1-1 | 42 |
| 26 Sat | Home | Bolton Wanderers | Barclays Premier League | Matchday 36 | 1-1 | 43 |
| May 2008 | ||||||
| 03 Sat | Away | Reading | Barclays Premier League | Matchday 37 | 0-1 | 46 |
| 11 Sun | Home | Liverpool | Barclays Premier League | Matchday 38 | 0-2 | 46 |